BACKGROUND: Numerous studies were carried out to develop more sophisticated dressings to expedite healing processes and diminish the bacterial burden in burn wounds. This study assessed the healing effect of NETTLE EXTRACT on second degree burns wound in rats in comparison with silver sulfadiazine and vaseline.METHODS: Forty rats were randomly assigned to four equal groups. A deep second-degree burn was created on the back of each rat using a standard burning procedure. The burns were dressed daily with NETTLE EXTRACT in group 1, silver sulfadiazine in group 2, vaseline in group 3 and without any medication in group 4 as control group.The response to treatment was assessed by digital photography during the treatment until day 42. Histological scoring was undertaken for scar tissue samples on days 10 and 42.RESULTS: A statistically significant difference was observed in group 1 compared with other groups regarding 4 scoring parameters after 10 days. A statistically significant difference was seen for fibrosis parameter after 42 days. In terms of difference of wound surface area, maximal healing was noticed at the same time in NETTLE group and minimal repair in the control group.CONCLUSION: Our findings showed maximal rate of healing in the NETTLE group. So it may be a suitable substitute for silver sulfadiazine and vaseline when available.

High levels of circulating fat are considered an important factor in atherosclerosis. So the most important object of the present study is to investigate the effect of NETTLE leaf EXTRACT mixture on atherosclerosis plaque formation and biochemical factors of cardiovascular diseases. Twenty-eight rabbits were randomly divided into four groups, normal diet as the control group, sunflower oil as a sham group, high cholesterolemic group (1% cholesterol), and high-cholesterol + NETTLE leaf EXTRACT (500 mg/kg of BW) group. Components were given to the sham and all 2 experimental groups as gavage. Obtained results of the present study indicated that body weight was reduced significantly in group III compared with the control groups and group II. In the slices prepared from the aorta of the 1% cholesterol-treated group, athreptic plaques were detectable. The plaques were formed of lipid-laden macrophages, and foam cells, with smooth muscle cells within the plaques. The thickness of the plaque increased so that it was more than half of the thickness of the environment. Pathology results showed that the NETTLE EXTRACT reduced significantly the damage in the arterial wall compared with the high-cholesterol group. The atheroma was fully raised and observable in the inner surface of the vessel (P<0/01). The results indicated that Grande ortie EXTRACT is efficient and tended to improve atherosclerosis complications in hypercholesterolemia rabbits.

High levels of circulating fat are considered an important factor in atherosclerosis. So the most important object of the present study is to investigate the effect of NETTLE leaf EXTRACT mixture on atherosclerosis plaque formation and biochemical factors of cardiovascular diseases. Twenty-eight rabbits were randomly divided into four groups, normal diet as the control group, sunflower oil as a sham group, high cholesterolemic group (1% cholesterol), and high-cholesterol + NETTLE leaf EXTRACT (500 mg/kg of BW) group. Components were given to the sham and all 2 experimental groups as gavage. Obtained results of the present study indicated that body weight was reduced significantly in group III compared with the control groups and group II. In the slices prepared from the aorta of the 1% cholesterol-treated group, athreptic plaques were detectable. The plaques were formed of lipid-laden macrophages, and foam cells, with smooth muscle cells within the plaques. The thickness of the plaque increased so that it was more than half of the thickness of the environment. Pathology results showed that the NETTLE EXTRACT reduced significantly the damage in the arterial wall compared with the high-cholesterol group. The atheroma was fully raised and observable in the inner surface of the vessel (P<0/01). The results indicated that Grande ortie EXTRACT is efficient and tended to improve atherosclerosis complications in hypercholesterolemia rabbits.